No, in manual mode you loose some of the safety setting (filter pressure shut off, blocked intake shut off). For me, running the pump 24/7 and in auto, and being around the house all day, (I'm retired) I set my pump up like this but I don't change it very often. My pool is 20 X 40 inground, about 30,000 gals. I set the pump up for one turnover in a 24 hour day. The pump looks at how many hours I want to run and the number of turn overs I want to how much water I have in the pool and runs to that gal-per-min. To run at 1 turn over for 12 hour day at 30,000 gal, the pump would pump twice the amount of gal-per-min. The setting for the amount of water in the pool is what I change to run the pump higher or lower. To run 31 gal-per-min I set the pool water amount at 45k. For 40 gal-per-min I set the pool water amount to 58k. You can only set the total pool water amount in thousands. Since the returns are two 1.5 inch lines and they are 28 years old, I don't push more than 50 gal-per-min. Also, since I can push alot of water, I use the largest return eyeballs I can find to keep the pressure down. I think the eyeballs have 1.25 inch eyes. I hope I said all this so I make myself clear.
Like I said before, that pump will do more than I'll ever want or need it to do. But running 375 watts comparred to 2050 watts sure saves some money on electricty bills.