Question 1....For the eyes size won't matter, GPM will be the same. Velocity will vary.
Is that because they're separately plumbed? Will there still be a small impact of eye size at the return manifold? My mental picture is that a smaller eye will increase the pressure at the eye itself, which will increase the pressure all the way back at the manifold. But that is probably a small effect relative to the head pressure which is around 10ft. So there will be minimal difference in flow rates down the different return legs at the manifold?
If only velocity varies, and the above explanation is correct, that suggests using the smallest eye to get maximum velocity and hence the best skimming effect? Or is velocity irrelevant to skimming efficacy (ignoring winds)? If that's the case, it would suggest using the largest eye to reduce the pressure at the pump, since I have a 10ft head already. (Although now I think about it, the head should be irrelevant to the pump since it sees the same head on input and output, and the pump should only "feel" the difference in head between the two?)
As for question 2,.. assuming the north is to the top of the diagram, the NW return should face NNE. For the W return, I would go straight out. The SSW return should face South/ SSW, and the eastern should go straight out. This will likely give you the best distribution of chlorinated water.
Interesting. I will try that. I currently have the 3 W returns pointed NE/NNE, and the E return pointed SW, as an attempt to create a fully "circular" flow around the pool to direct surface material to the skimmers. I have tested how much much my chlorine concentration varies around the pool, and not measured a difference, although that's only at 18 inches depth (and only to the precision of the chlorine test which is not very precise, but presumably because greater precision is not relevant).
The prevailing winds will have a FAR BIGGER impact on the skimming effect than anything you can do with the return eyes.
At least in terms of moving surface debris to the skimmers, this is not consistent with my observations. We tend not to have windy summers where I am in NJ, so prevailing winds are light. The returns definitely circulate the surface water such that the debris ends up in the skimmers, unless it is very windy.